Identification of Ferroptosis-Related Biomarkers for Prognosis and Immunotherapy in Patients With Glioma.

ABSTRACT: Ferroptosis is a novel type of iron- and ROS-dependent cell death and is involved in various diseases. LncRNAs are involved and play important roles in the occurrence and development of several cancers. However, researches about the role of ferroptosis-related lncRNAs in glioma are relatively rare. Here, we identified nine ferroptosis-related lncRNAs and then constructed a prognostic model by the LASSO and Cox analysis. The model could predict overall survival with high sensitivity and specificity according to ROC curves. In addition, the cell cycle, p53 signaling, apoptosis, and oxidative phosphorylation pathways were obviously enriched in the pathogenesis of glioma by gene set enrichment analysis. A nomogram was constructed by integrating several independent prognostic clinicopathologica

SUBMITTER: Shi J 

PROVIDER: S-EPMC8842255 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature