Dataset Information

OCTA Derived Vessel Skeleton Density Versus Flux and Their Associations With Systemic Determinants of Health.

ABSTRACT:

Purpose

To examine the associations of optical coherence tomography angiography (OCTA)-derived retinal capillary flux with systemic determinants of health.

Methods

This is a cross-sectional study of subjects recruited from the African American Eye Disease Study. A commercially available swept-source (SS)-OCTA device was used to image the central 3 × 3 mm macular region. Retinal capillary perfusion was assessed using vessel skeleton density (VSD) and flux. Flux approximates the number of red blood cells moving through vessel segments and is a novel metric, whereas VSD is a previously validated measure commonly used to quantify capillary density. The associations of OCTA derived measures with systemic determinants of health were evaluated using multivariate generalized linear mixed-effects models.

Results

A total of 154 eyes from 83 participants were enrolled. Mean VSD and flux were 0.148 ± 0.009 and 0.156 ± 0.016, respectively. In a model containing age, systolic blood pressure, diabetes status, hematocrit, and presence of retinopathy as covariates, there was a negative correlation between VSD and age (P < 0.001) and retinopathy (P = 0.02), but not with hematocrit (P = 0.85) or other factors. There was a positive correlation between flux and hematocrit (P = 0.02), as well as a negative correlation for flux with age (P < 0.001), systolic blood pressure (P = 0.04), and diabetes status (P = 0.02). A 1% decrease in hematocrit was associated with the same magnitude change in flux as ∼1.24 years of aging. Signal strength was associated with flux (P < 0.001), but not VSD (P = 0.51).

Conclusions

SS-OCTA derived flux provides additional information about retinal perfusion distinct from that obtained with skeleton density-based measures. Flux is appropriate for detecting subclinical changes in perfusion in the absence of clinical retinopathy.

SUBMITTER: Kushner-Lenhoff S

PROVIDER: S-EPMC8842473 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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Publications

OCTA Derived Vessel Skeleton Density Versus Flux and Their Associations With Systemic Determinants of Health.

Kushner-Lenhoff Sam S Li Yuandong Y Zhang Qinqin Q Wang Ruikang K RK Jiang Xuejuan X Kashani Amir H AH

Investigative ophthalmology & visual science 20220201 2

<h4>Purpose</h4>To examine the associations of optical coherence tomography angiography (OCTA)-derived retinal capillary flux with systemic determinants of health.<h4>Methods</h4>This is a cross-sectional study of subjects recruited from the African American Eye Disease Study. A commercially available swept-source (SS)-OCTA device was used to image the central 3 × 3 mm macular region. Retinal capillary perfusion was assessed using vessel skeleton density (VSD) and flux. Flux approximates the num ...[more]

PMID: 35142788

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Dataset Information

OCTA Derived Vessel Skeleton Density Versus Flux and Their Associations With Systemic Determinants of Health.

Purpose

Methods

Results

Conclusions

Publications

OCTA Derived Vessel Skeleton Density Versus Flux and Their Associations With Systemic Determinants of Health.

Similar Datasets

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