Network Controllability in Transmodal Cortex Predicts Positive Psychosis Spectrum Symptoms.

ABSTRACT:

Background

The psychosis spectrum (PS) is associated with structural dysconnectivity concentrated in transmodal cortex. However, understanding of this pathophysiology has been limited by an overreliance on examining direct interregional connectivity. Using network control theory, we measured variation in both direct and indirect connectivity to a region to gain new insights into the pathophysiology of the PS.

Methods

We used psychosis symptom data and structural connectivity in 1068 individuals from the Philadelphia Neurodevelopmental Cohort. Applying a network control theory metric called average controllability, we estimated each brain region's capacity to leverage its direct and indirect structural connections to control linear brain dynamics. Using nonlinear regression,

SUBMITTER: Parkes L 

PROVIDER: S-EPMC8842484 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature