A long-term follow-up analysis of associations between tooth loss and multiple cancers in the Linxian General Population Cohort.

ABSTRACT: Poor oral health, indicated by tooth loss and periodontal disease, may be an important risk factor for various cancers. Prior studies have found inconsistent associations between tooth loss and several cancer types. Here, we examined the relationship between tooth loss and incident cases of multiple cancers in the Linxian General Population Nutrition Intervention Trial cohort. In this large prospective cohort of over 29,000 participants, there were 3101, 1701, 626, 327, 348, and 179 incident esophageal, gastric cardia, gastric noncardia, liver, lung, and colorectal cancer cases, respectively, over 30 years of follow-up. Adjusted Cox proportional hazards regression models with time-varying covariates were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the associ

SUBMITTER: Yano Y 

PROVIDER: S-EPMC8842496 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature