Genion, an accurate tool to detect gene fusion from long transcriptomics reads.

ABSTRACT:

Background

The advent of next-generation sequencing technologies empowered a wide variety of transcriptomics studies. A widely studied topic is gene fusion which is observed in many cancer types and suspected of having oncogenic properties. Gene fusions are the result of structural genomic events that bring two genes closely located and result in a fused transcript. This is different from fusion transcripts created during or after the transcription process. These chimeric transcripts are also known as read-through and trans-splicing transcripts. Gene fusion discovery with short reads is a well-studied problem, and many methods have been developed. But the sensitivity of these methods is limited by the technology, especially the short read length. Advances in long-read sequencing te

SUBMITTER: Karaoglanoglu F 

PROVIDER: S-EPMC8842519 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature