Severe Gestational Low-Protein Intake Impacts Hippocampal Cellularity, Tau, and Amyloid-β Levels, and Memory Performance in Male Adult Offspring: An Alzheimer-Simile Disease Model?

ABSTRACT:

Background

Maternal undernutrition has been associated with psychiatric and neurological disorders characterized by learning and memory impairment.

Objective

Considering the lack of evidence, we aimed to analyze the effects of gestational protein restriction on learning and memory function associated with hippocampal cell numbers and neurodegenerative protein content later in life.

Methods

Experiments were conducted in gestational low- (LP, 6% casein) or regular-protein (NP, 17% casein) diet intake offspring. Behavioral tests, isolated hippocampal isotropic fractionator cell studies, immunoblotting, and survival lifetime were observed.

Results

The birthweight of LP males is significantly reduced relative to NP male progeny, and hippocampal mass increased in 88-

SUBMITTER: Grigoletti-Lima GB 

PROVIDER: S-EPMC8842744 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature