A Patient-Centered Conceptual Model of Symptoms and Their Impact in Early Parkinson's Disease: A Qualitative Study.

ABSTRACT:

Background

Individuals with Parkinson's disease (PD) develop a significant disease burden over time that contributes to a progressive decline in health-related quality of life. There is a paucity of qualitative research to understand symptoms and impacts in individuals with early-stage PD (i.e., Hoehn and Yahr stage 1-2 and ≤2 years since diagnosis).

Objective

The collection of qualitative data to inform the selection of clinical outcome assessments for clinical trials is advocated by regulators. This patient-centered, multistage study sought to create a conceptual model of symptoms and their impact for individuals with early-stage PD.

Methods

Symptoms and impacts of PD were gathered from a literature review of qualitative research, a quantitative social media listeni

SUBMITTER: Staunton H 

PROVIDER: S-EPMC8842769 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature