Sex-Related Longitudinal Change of Motor, Non-Motor, and Biological Features in Early Parkinson's Disease.

ABSTRACT:

Background

Investigation of sex-related motor and non-motor differences and biological markers in Parkinson's disease (PD) may improve precision medicine approach.

Objective

To examine sex-related longitudinal changes in motor and non-motor features and biologic biomarkers in early PD.

Methods

We compared 5-year longitudinal changes in de novo, untreated PD men and women (at baseline N = 423; 65.5%male) of the Parkinson's Progression Markers Initiative (PPMI), assessing motor and non-motor manifestations of disease; and biologic measures in cerebrospinal fluid (CSF) and dopamine transporter deficit on DaTscanTM uptake.

Results

Men experienced greater longitudinal decline in self-reported motor (p < 0.001) and non-motor (p = 0.009) aspects of experiences of dail

SUBMITTER: Picillo M 

PROVIDER: S-EPMC8842783 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature