CircPTPN4 regulates myogenesis via the miR-499-3p/NAMPT axis.

ABSTRACT:

Background

Circular RNAs (circRNAs) are a novel class of endogenous ncRNA, which widely exist in the transcriptomes of different species and tissues. Recent studies indicate important roles for circRNAs in the regulation of gene expression by acting as competing endogenous RNAs (ceRNAs). However, the specific role of circRNAs in myogenesis is still poorly understood. In this study, we attempted to systematically identify the circRNAs involved in myogenesis and analyze the biological functions of circRNAs in chicken skeletal muscle development.

Results

In total, 532 circRNAs were identified as being differentially expressed between pectoralis major (PEM) and soleus (SOL) in 7-week-old Xinghua chicken. Among them, a novel circRNA (novel_circ_002621), generated by PTPN4 gene, w

SUBMITTER: Cai B 

PROVIDER: S-EPMC8842800 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature