Network dysfunction in cognitively normal APOE ε4 carriers is related to subclinical tau.

ABSTRACT:

Introduction

Apolipoprotein E (APOE) ε4 allele status is associated with amyloid and tau-related pathological changes related to Alzheimer's disease (AD). However, it is unknown whether brain network changes are related to amyloid beta (Aβ) and/or tau-related pathology in cognitively normal APOE ε4 carriers with subthreshold Aβ accumulation.

Methods

Resting state functional connectivity measures of network integrity were evaluated in cognitively normal individuals (n = 121, mean age 76.6 ± 7.8 years, 15% APOE ε4 carriers, 65% female) with minimal Aβ per cerebrospinal fluid (CSF) or amyloid positron emission tomography.

Results

APOE ε4 carriers had increased lateralized connections relative to callosal connections within the default-mode, memory, and salience networks

SUBMITTER: Butt OH 

PROVIDER: S-EPMC8842835 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature