Early pregnancy exposure to metal mixture and birth outcomes - A prospective study in Project Viva.

ABSTRACT:

Background

Prenatal exposure to metals has been individually associated with birth outcomes. However, little is known about the effect of metal mixture, particularly at low exposure levels.

Objectives

To estimate individual and joint effects of metal mixture components on birth outcomes.

Methods

We used data from 1,391 mother-infant pairs in Project Viva (1999-2002). We measured 11 metals in maternal 1st trimester erythrocyte; abstracted birth weight from medical records; calculated gestational age from last menstrual period or ultrasound; and obtained birth length (n = 729) and head circumference (n = 791) from research measurements. We estimated individual and joint effects of metals using multivariable linear and Bayesian kernel machine regressions.

Results

SUBMITTER: Rahman ML 

PROVIDER: S-EPMC8842844 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature