Chondrocyte-derived exosomes promote cartilage calcification in temporomandibular joint osteoarthritis.

ABSTRACT:

Backgrounds

Abnormal cartilage calcification is one of the pathological changes of temporomandibular joint (TMJ) osteoarthritis (OA). Recent studies have reported that exosomes can regulate the formation of abnormal calcified nodules in diseases including atherosclerosis and chronic kidney disease. However, the influences of chondrocyte-derived exosomes on abnormal cartilage calcification in TMJ OA are still unclear.

Methods

TMJ OA was induced by unilateral anterior crossbite (UAC) for 4, 8, or 12 weeks in rats to observe abnormal calcification in TMJ condylar cartilage and exosome formation. Concomitantly, GW4869, the inhibitor of exosome formation, was locally injected to the TMJ of rats under stimulation of UAC, while the exosomes extracted from primary condylar chondrocy

SUBMITTER: Liu Q 

PROVIDER: S-EPMC8842872 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature