Profiling of exosomal microRNAs expression in umbilical cord blood from normal and preeclampsia patients.

ABSTRACT:

Background

Epidemiological and experimental studies suggest that preeclampsia has a negative impact on maternity and offspring health. Previous studies report that dysregulation in utero-environment increases risk for elderly disease such as cardiovascular disease. However, the underlying mechanisms remain elusive. Specific microRNAs (miRNAs) are packaged in exosomes may regulate microvascular dysfunction in offspring of mothers with preeclampsia. The present study aimed to identify the differential expression profiles of microRNAs in the serum exosomes between patients with preeclampsia and normal pregnancies.

Methods

A comprehensive miRNA sequence-based approach was performed to compare exosomes carry miRNAs (Exo-miRNAs) expression levels in umbilical serum between normal

SUBMITTER: Pan HT 

PROVIDER: S-EPMC8842963 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature