Direct Oral Anticoagulants Versus Warfarin in the Treatment of Left Ventricular Thrombus.

ABSTRACT:

Background

Use of direct oral anticoagulants (DOACs) for the treatment of left ventricular (LV) thrombus has gained considerable interest.

Objective

We aimed to evaluate if DOACs are effective in the treatment of LV thrombus compared with warfarin.

Methods

We evaluated the medical records of patients diagnosed with a new LV thrombus at a tertiary medical center. The primary outcome was the composite of thrombus persistence, stroke, or systemic embolism. We adjusted for potential confounders using multiple logistic regression. The safety outcome was the composite of hemorrhagic stroke or bleeding requiring blood transfusion.

Results

A total of 129 patients were treated with warfarin and 22, with a DOAC. In unadjusted analysis, 54.3% of patients treated with warf

SUBMITTER: Willeford A 

PROVIDER: S-EPMC8842988 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature