Adiponectin suppresses tumor growth of nasopharyngeal carcinoma through activating AMPK signaling pathway.

ABSTRACT:

Background

Adiponectin is an adipocyte-secreted cytokine that enhances insulin sensitivity and attenuates inflammation. Although circulating adiponectin level is often inversely associated with several malignancies, its role in the development of nasopharyngeal carcinoma (NPC) remains unclear. Here, we investigated the clinical association between circulating adiponectin level and NPC, and examined the impact of adiponectin, as well as the underlying mechanisms, on NPC growth both in vitro and in vivo.

Methods

The association between circulating adiponectin level and the risk of developing NPC was assessed in two different cohorts, including a hospital-based case-control study with 152 cases and 132 controls, and a nested case-control study with 71 cases and 142 controls wit

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC8843017 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature