Effects of Antibiotic Use on Saliva Antibody Content and Oral Microbiota in Sprague Dawley Rats.

ABSTRACT: Antibiotics are often used to treat systemic diseases not associated with the oral cavity. This application of antibiotics may affect the healthy oral microbiota community, as it destroys the balance between specific bacterial populations throughout the ecosystem and may lead to dysbacteriosis. We hypothesized that the effects on antibiotics on oral microbiota regulation and function would affect antibody content in saliva, depending on the antibiotic type. To address this, a total of 24 Sprague Dawley rats (divided into 4 cages, 6 per pen) were administered amoxicillin (AMX), spiramycin (SP), metronidazole (MTZ), or water (control) daily for 14 days (gavage). After treatment was completed, high-throughput sequencing of 16S rRNA genes was used to determine changes in the composition, metab

SUBMITTER: Cheng X 

PROVIDER: S-EPMC8843035 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature