Mapping dopaminergic projections in the human brain with resting-state fMRI.

ABSTRACT: The striatum receives dense dopaminergic projections, making it a key region of the dopaminergic system. Its dysfunction has been implicated in various conditions including Parkinson's disease (PD) and substance use disorder. However, the investigation of dopamine-specific functioning in humans is problematic as current MRI approaches are unable to differentiate between dopaminergic and other projections. Here, we demonstrate that 'connectopic mapping' - a novel approach for characterizing fine-grained, overlapping modes of functional connectivity - can be used to map dopaminergic projections in striatum. We applied connectopic mapping to resting-state functional MRI data of the Human Connectome Project (population cohort; N = 839) and selected the second-order striatal connectivity mode f

SUBMITTER: Oldehinkel M 

PROVIDER: S-EPMC8843090 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature