Three-dimensional multi-site random access photostimulation (3D-MAP).

ABSTRACT: Optical control of neural ensemble activity is crucial for understanding brain function and disease, yet no technology can achieve optogenetic control of very large numbers of neurons at an extremely fast rate over a large volume. State-of-the-art multiphoton holographic optogenetics requires high-power illumination that only addresses relatively small populations of neurons in parallel. Conversely, one-photon holographic techniques can stimulate more neurons with two to three orders lower power, but with limited resolution or addressable volume. Perhaps most problematically, two-photon holographic optogenetic systems are extremely expensive and sophisticated which has precluded their broader adoption in the neuroscience community. To address this technical gap, we introduce a new one-phot

SUBMITTER: Xue Y 

PROVIDER: S-EPMC8843094 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature