Risk of HCC With Hepatitis B Viremia Among HIV/HBV-Coinfected Persons in North America.

ABSTRACT:

Background and aims

Chronic HBV is the predominant cause of HCC worldwide. Although HBV coinfection is common in HIV, the determinants of HCC in HIV/HBV coinfection are poorly characterized. We examined the predictors of HCC in a multicohort study of individuals coinfected with HIV/HBV.

Approach and results

We included persons coinfected with HIV/HBV within 22 cohorts of the North American AIDS Cohort Collaboration on Research and Design (1995-2016). First occurrence of HCC was verified by medical record review and/or cancer registry. We used multivariable Cox regression to determine adjusted HRs (aHRs [95% CIs]) of factors assessed at cohort entry (age, sex, race, body mass index), ever during observation (heavy alcohol use, HCV), or time-updated (HIV RNA, CD4+ percentage,

SUBMITTER: Kim HN 

PROVIDER: S-EPMC8843101 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature