Type I interferons and MAVS signaling are necessary for tissue resident memory CD8+ T cell responses to RSV infection.

ABSTRACT: Respiratory syncytial virus (RSV) can cause bronchiolitis and viral pneumonia in young children and the elderly. Lack of vaccines and recurrence of RSV infection indicate the difficulty in eliciting protective memory immune responses. Tissue resident memory T cells (TRM) can confer protection from pathogen re-infection and, in human experimental RSV infection, the presence of lung CD8+ TRM cells correlates with a better outcome. However, the requirements for generating and maintaining lung TRM cells during RSV infection are not fully understood. Here, we use mouse models to assess the impact of innate immune response determinants in the generation and subsequent expansion of the TRM cell pool during RSV infection. We show that CD8+ TRM cells expand independently from systemic CD8+ T cells

SUBMITTER: Varese A 

PROVIDER: S-EPMC8843175 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature