Aetiology of severe community acquired pneumonia in adults identified by combined detection methods: a multi-centre prospective study in China.

ABSTRACT: Severe Community Acquired Pneumonia (SCAP) challenges public health globally. Considerable improvements in molecular pathogen testing emerged in the last few years. Our prospective study combinedly used traditional culture, antigen tests, PCR and mNGS in SCAP pathogen identification with clinical outcomes. From June 2018 to December 2019, we conducted a multi-centre prospective study in 17 hospitals of SCAP patients within 48 hours of emergency room stay or hospitalization in China. All clinical data were uploaded into an online database. Blood, urine and respiratory specimens were collected for routine culture, antigen detection, PCR and mNGS as designed appropriately. Aetiology confirmation was made by the local attending physician group and scientific committee according to microbiologi

SUBMITTER: Qu J 

PROVIDER: S-EPMC8843176 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature