Hour-1 bundle adherence was associated with reduction of in-hospital mortality among patients with sepsis in Japan.

ABSTRACT:

Background

The updated Surviving Sepsis Campaign guidelines recommend a 1-hour window for completion of a sepsis care bundle; however, the effectiveness of the hour-1 bundle has not been fully evaluated. The present study aimed to evaluate the impact of hour-1 bundle completion on clinical outcomes in sepsis patients.

Methods

This was a multicenter, prospective, observational study conducted in 17 intensive care units in tertiary hospitals in Japan. We included all adult patients who were diagnosed as having sepsis by Sepsis-3 and admitted to intensive care units from July 2019 to August 2020. Impacts of hour-1 bundle adherence and delay of adherence on risk-adjusted in-hospital mortality were estimated by multivariable logistic regression analyses.

Results

The final

SUBMITTER: Umemura Y 

PROVIDER: S-EPMC8843226 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature