Cadmium Exposure in Young Adulthood Is Associated with Risk of Nonalcoholic Fatty Liver Disease in Midlife.

ABSTRACT:

Background

Studies have suggested that cadmium (Cd) may be involved in the etiology of nonalcoholic fatty liver disease (NAFLD), but available data in human is sparse.

Aims

We aimed to examine Cd exposure in young adulthood in relation to prevalent NAFLD in midlife among American adults.

Methods

This study included 2446 participants from the Coronary Artery Risk Development in Young Adults study with toenail Cd measurement at exam year 2 (baseline) and computed tomography quantification of liver fat at exam year 25. Toenail Cd concentrations were considered as a reliable marker of long-term exposure. NAFLD was defined if liver attenuation < 51 Hounsfield units after excluding other possible causes of liver fat. Multivariable-adjusted logistic regression models were us

SUBMITTER: Li Y 

PROVIDER: S-EPMC8843233 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature