Modular head-mounted cortical imaging device for chronic monitoring of intrinsic signals in mice.

ABSTRACT:

Significance

Intrinsic optical signals (IOS) generated in the cortical tissue as a result of various interacting metabolic processes are used extensively to elucidate the underlying mechanisms that govern neurovascular coupling. However, current IOS measurements still often rely on bulky, tabletop imaging systems, and there remains a dearth of studies in freely moving subjects. Lightweight, miniature head-mounted imaging devices provide unique opportunities for investigating cortical dynamics in small animals under a variety of naturalistic behavioral settings.

Aim

The aim of this work was to monitor IOS in the somatosensory cortex of wild-type mice by developing a lightweight, biocompatible imaging device that readily lends itself to animal experiments in freely moving cond

SUBMITTER: Guinto MC 

PROVIDER: S-EPMC8843356 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature