Microstructure and Genetic Polymorphisms: Role in Motor Rehabilitation After Subcortical Stroke.

ABSTRACT: Background and Purpose: Motor deficits are the most common disability after stroke, and early prediction of motor outcomes is critical for guiding the choice of early interventions. Two main factors that may impact the response to rehabilitation are variations in the microstructure of the affected corticospinal tract (CST) and genetic polymorphisms in brain-derived neurotrophic factor (BDNF). The purpose of this article was to review the role of these factors in stroke recovery, which will be useful for constructing a predictive model of rehabilitation outcomes. Summary of Review: We review the microstructure of the CST, including its origins in the primary motor area (M1), primary sensory area (S1), premotor cortex (PMC), and supplementary motor area (SMA). Damage to these f

SUBMITTER: Liu J 

PROVIDER: S-EPMC8843845 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature