Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-κB pathway.

ABSTRACT: Cellular senescence is closely associated with age-related diseases. Ovarian aging, a special type of organ senescence, is the pathophysiological foundation of the diseases of the reproductive system. It is characterized by the loss of integrity of the surface epithelium and a gradual decrease in the number of human ovarian surface epithelial cells (HOSEpiCs). To contribute to the research on delaying ovarian aging, we aimed to investigate the novel epigenetic mechanism of melatonin in protecting HOSEpiCs. We discovered that melatonin has antagonistic effects against the oncogene-induced senescence (OIS) of HOSEpiCs. Mechanistically, the oncogene Ras decreased the expression of YTHDF2, which is the reader of RNA-m⁶A, by stimulating the generation of reactive oxygen species (ROS)

SUBMITTER: Zhu R 

PROVIDER: S-EPMC8843885 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature