Preventive Vitamin A Supplementation Improves Striatal Function in 6-Hydroxydopamine Hemiparkinsonian Rats.

ABSTRACT:

Background

The mechanisms leading to a loss of dopaminergic (DA) neurons from the substantia nigra pars compacta (SNc) in Parkinson's disease (PD) have multifactorial origins. In this context, nutrition is currently investigated as a modifiable environmental factor for the prevention of PD. In particular, initial studies revealed the deleterious consequences of vitamin A signaling failure on dopamine-related motor behaviors. However, the potential of vitamin A supplementation itself to prevent neurodegeneration has not been established yet.

Objective

The hypothesis tested in this study is that preventive vitamin A supplementation can protect DA neurons in a rat model of PD.

Methods

The impact of a 5-week preventive supplementation with vitamin A (20 IU/g of die

SUBMITTER: Marie A 

PROVIDER: S-EPMC8843942 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature