Muscle mitochondrial energetics predicts mobility decline in well-functioning older adults: The baltimore longitudinal study of aging.

ABSTRACT:

Background

Muscle mitochondrial dysfunction is associated with poor mobility in aging. Whether mitochondrial dysfunction predicts subsequent mobility decline is unknown.

Methods

We examined 380 cognitively normal participants aged 60 and older (53%women, 22%Black) who were well-functioning (gait speed ≥ 1.0 m/s) and free of Parkinson's disease and stroke at baseline and had data on baseline skeletal muscle oxidative capacity and one or more mobility assessments during an average 2.5 years. Muscle oxidative capacity was measured by phosphorus magnetic resonance spectroscopy as the post-exercise recovery rate of phosphocreatine (k_PCr ). Mobility was measured by four walking tests. Associations of baseline k_PCr with mobility changes were examined using lin

SUBMITTER: Tian Q 

PROVIDER: S-EPMC8844110 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature