Proper control of R-loop homeostasis is required for maintenance of gene expression and neuronal function during aging.

ABSTRACT: Age-related loss of cellular function and increased cell death are characteristic hallmarks of aging. While defects in gene expression and RNA metabolism have been linked with age-associated human neuropathies, it is not clear how the changes that occur in aging neurons contribute to loss of gene expression homeostasis. R-loops are RNA-DNA hybrids that typically form co-transcriptionally via annealing of the nascent RNA to the template DNA strand, displacing the non-template DNA strand. Dysregulation of R-loop homeostasis has been associated with both transcriptional impairment and genome instability. Importantly, a growing body of evidence links R-loop accumulation with cellular dysfunction, increased cell death, and chronic disease onset. Here, we characterized the R-loop landscape in ag

SUBMITTER: Jauregui-Lozano J 

PROVIDER: S-EPMC8844117 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature