The metabolome as a biomarker of aging in Drosophila melanogaster.

ABSTRACT: Many biomarkers have been shown to be associated not only with chronological age but also with functional measures of biological age. In human populations, it is difficult to show whether variation in biological age is truly predictive of life expectancy, as such research would require longitudinal studies over many years, or even decades. We followed adult cohorts of 20 Drosophila Genetic Reference Panel (DGRP) strains chosen to represent the breadth of lifespan variation, obtain estimates of lifespan, baseline mortality, and rate of aging, and associate these parameters with age-specific functional traits including fecundity and climbing activity and with age-specific targeted metabolomic profiles. We show that activity levels and metabolome-wide profiles are strongly associated with age

SUBMITTER: Zhao X 

PROVIDER: S-EPMC8844127 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature