Aberrant hepatic trafficking of gut-derived T cells is not specific to primary sclerosing cholangitis.

ABSTRACT:

Background and aims

The "gut homing" hypothesis suggests the pathogenesis of primary sclerosing cholangitis (PSC) is driven by aberrant hepatic expression of gut adhesion molecules and subsequent recruitment of gut-derived T cells to the liver. However, inconsistencies lie within this theory including an absence of investigations and comparisons with other chronic liver diseases (CLD). Here, we examine "the gut homing theory" in patients with PSC with associated inflammatory bowel disease (PSC-IBD) and across multiple inflammatory liver diseases.

Approach and results

Expression of MAdCAM-1, CCL25, and E-Cadherin were assessed histologically and using RT-PCR on explanted liver tissue from patients with CLD undergoing OLT and in normal liver. Liver mononuclear cells were isola

SUBMITTER: Graham JJ 

PROVIDER: S-EPMC8844147 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature