A tale of two gradients: differences between the left and right hemispheres predict semantic cognition.

ABSTRACT: Decomposition of whole-brain functional connectivity patterns reveals a principal gradient that captures the separation of sensorimotor cortex from heteromodal regions in the default mode network (DMN). Functional homotopy is strongest in sensorimotor areas, and weakest in heteromodal cortices, suggesting there may be differences between the left and right hemispheres (LH/RH) in the principal gradient, especially towards its apex. This study characterised hemispheric differences in the position of large-scale cortical networks along the principal gradient, and their functional significance. We collected resting-state fMRI and semantic, working memory and non-verbal reasoning performance in 175 + healthy volunteers. We then extracted the principal gradient of connectivity for each participa

SUBMITTER: Gonzalez Alam TRDJ 

PROVIDER: S-EPMC8844158 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature