De novo strategy with engineering a multifunctional bacterial cellulose-based dressing for rapid healing of infected wounds.

ABSTRACT: The treatment and healing of infected skin lesions is one of the major challenges in surgery. To solve this problem, collagen I (Col-I) and the antibacterial agent hydroxypropyltrimethyl ammonium chloride chitosan (HACC) were composited into the bacterial cellulose (BC) three-dimensional network structure by a novel membrane-liquid interface (MLI) culture, and a Col-I/HACC/BC (CHBC) multifunctional dressing was designed. The water absorption rate and water vapor transmission rate of the obtained CHBC dressing were 35.78 ± 2.45 g/g and 3084 ± 56 g m^-2·day^-1, respectively. The water retention of the CHBC dressing was significantly improved compared with the BC caused by the introduced Col-I and HACC. In vitro results indicated that the combined advantages of HACC

SUBMITTER: Zhou C 

PROVIDER: S-EPMC8844193 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature