CA1 Spike Timing is Impaired in the 129S Inbred Strain During Cognitive Tasks.

ABSTRACT: A spontaneous mutation of the disrupted in schizophrenia 1 (Disc1) gene is carried by the 129S inbred mouse strain. Truncated DISC1 protein in 129S mouse synapses impairs the scaffolding of excitatory postsynaptic receptors and leads to progressive spine dysgenesis. In contrast, C57BL/6 inbred mice carry the wild-type Disc1 gene and exhibit more typical cognitive performance in spatial exploration and executive behavioral tests. Because of the innate Disc1 mutation, adult 129S inbred mice exhibit the behavioral phenotypes of outbred B6 Disc1 knockdown (Disc1^-/-) or Disc1-L-100P mutant strains. Recent studies in Disc1^-/- and L-100P mice have shown that impaired excitation-driven interneuron activity and low hippocampal theta power underlie the behavioral phenotypes tha

SUBMITTER: Adeyelu T 

PROVIDER: S-EPMC8844212 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature