Measurement of PET Quantitative Bias In Vivo.

ABSTRACT: Quantitative imaging biomarkers are widely used in PET for both research and clinical applications, yet bias in the underlying image data has not been well characterized. In the absence of a readily available reference standard for in vivo quantification, bias in PET images has been inferred using physical phantoms, even though arrangements of this sort provide only a poor approximation of the imaging environment in real patient examinations. In this study, we used data acquired from patient volunteers to assess PET quantitative bias in vivo. Image-derived radioactivity concentrations in the descending aorta were compared with blood samples counted on a calibrated γ-counter. Methods: Ten patients with prostate cancer were studied using 2-(3-(1-carboxy-5-[(6-¹⁸F-fluoro-pyr

SUBMITTER: Lodge MA 

PROVIDER: S-EPMC8844265 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature