Reporting Rates of Opioid-Related Adverse Events Since 1965 in Canada: A Descriptive Retrospective Study.

ABSTRACT:

Background

Patients with chronic or acute/postoperative pain frequently use opioids. However, opioids may cause considerable adverse reactions (ARs), such as respiratory depression, which could be lethal. Unfortunately, only 5% of drug-related ARs (including those to opioids) are reported to health authorities. Therefore, little is known regarding the occurrence of opioid-related ARs at the population level.

Objective

The aim of this study was to investigate how the rates of reported opioid-related ARs have changed in Canada since 1965.

Methods

Our retrospective study examined trends of reported opioid-related ARs occurring in hospitalized and outpatients. Data on opioid-related ARs and mortality between 1965 and 2019 were obtained from the Canada Vigilance and Statis

SUBMITTER: Lavallee M 

PROVIDER: S-EPMC8844319 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature