Insulinopathies of the brain? Genetic overlap between somatic insulin-related and neuropsychiatric disorders.

ABSTRACT: The prevalence of somatic insulinopathies, like metabolic syndrome (MetS), obesity, and type 2 diabetes mellitus (T2DM), is higher in Alzheimer's disease (AD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD). Dysregulation of insulin signalling has been implicated in these neuropsychiatric disorders, and shared genetic factors might partly underlie this observed multimorbidity. We investigated the genetic overlap between AD, ASD, and OCD with MetS, obesity, and T2DM by estimating pairwise global genetic correlations using the summary statistics of the largest available genome-wide association studies for these phenotypes. Having tested these hypotheses, other potential brain "insulinopathies" were also explored by estimating the genetic relationship of six additiona

SUBMITTER: Fanelli G 

PROVIDER: S-EPMC8844407 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature