Ontology highlight
ABSTRACT:
SUBMITTER: Lu C
PROVIDER: S-EPMC8844449 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Lu Can C Chen Xi X Yan Yuanliang Y Ren Xinxin X Wang Xiang X Peng Bi B Cai Yuan Y Liang Qiuju Q Xu Zhijie Z Peng Jinwu J
Frontiers in pharmacology 20220201
Chemoresistance, especially temozolomide (TMZ) resistance, is a major clinical challenge in the treatment of glioblastoma (GBM). Exploring the mechanisms of TMZ resistance could help us identify effective therapies. Adenosine deaminases acting on RNA (ADARs) are very important in RNA modification through regulating the A-to-I RNA editing. Recent studies have shown that ADARs regulate multiple neurotransmitter receptors, which have been linked with the occurrence and progress of GBM. Here, data f ...[more]