A General Method to Develop Highly Environmentally Sensitive Fluorescent Probes and AIEgens.

ABSTRACT: Environmentally sensitive fluorescent probes (including AIEgens) play pivotal roles in numerous biological studies. Many of these functional materials are developed based on the twisted intramolecular charge transfer (TICT) mechanism. However, the TICT tendency of dialkylated amino groups in biocompatible main-stream fluorophores (i.e., coumarins and rhodamines) is weak, limiting their sensitivities. Herein, by replacing dialkylated amino donors with an N-methylpyrrole group to enhance TICT, a simple and general method to engineer highly environmentally sensitive fluorescent probes is reported. This method yields a platter of colorful fluorescent probes that demonstrates outstanding polarity and viscosity sensitivity with large turn-on ratios (up to 191 times for polarity and 14 times for

SUBMITTER: Miao R 

PROVIDER: S-EPMC8844555 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature