T-Cell Immune Dysregulation and Mortality in Women With Human Immunodeficiency Virus.

ABSTRACT:

Summary

In women with HIV, higher activation and exhaustion of CD4+ T cells were associated with risk of non-HIV-related mortality during a median of 13.3 years of follow-up, independent of baseline demographic, behavioral, HIV-related, and cardiometabolic factors and longitudinal HIV disease progression.

Background

Dysregulation of adaptive immunity is a hallmark of human immunodeficiency virus (HIV) infection that persists on antiretroviral therapy (ART). Few long-term prospective studies have related adaptive immunity impairments to mortality in HIV, particularly in women.

Methods

Among 606 women with HIV in the Women's Interagency HIV Study, peripheral blood mononuclear cells collected from 2002 to 2005 underwent multiparameter flow cytometry. Underlying cause of

SUBMITTER: Peters BA 

PROVIDER: S-EPMC8844590 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature