A novel mechanism for NLRP3 inflammasome activation.

ABSTRACT: The NLRP3 inflammasome, as an important component of the innate immune system, plays vital roles in various metabolic disorders. It has been reported that the NLRP3 inflammasome can be activated by a broad range of distinct stimuli, such as K⁺ efflux, mitochondrial dysfunction, lysosomal disruption and trans-Golgi disassembly, etc. However, there has been no well-established model for NLRP3 inflammasome activation so far, especially the underlying mechanisms for mitochondria in NLRP3 inflammasome activation remain elusive. Given that K⁺ efflux is a widely accepted nexus for triggering activation of NLRP3 inflammasome in most previous studies, we sought to elucidate the role of mitochondria in K⁺ efflux-induced NLRP3 inflammasome activation. Here, we demonst

SUBMITTER: Zhang T 

PROVIDER: S-EPMC8844605 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature