Novel long non-coding RNAs of relevance for ulcerative colitis pathogenesis.

ABSTRACT:

Background and aims

The study aimed to identify yet unknown and uncharacterized long non-coding RNAs (lncRNAs) in treatment-naïve ulcerative colitis (UC), and to define their possible roles in UC pathogenesis. For that purpose, accurate quantification methods for lncRNA transcript detection, multiple and "stringent" strategies were applied. New insights in the regulation of functional genes and pathways of relevance for UC through expression of lncRNAs are expected.

Methods

The study was based on sequencing data derived from a data set consisting of treatment-naïve UC patients (n = 14) and control subjects (n = 16). Two complementary aligners were used to identify lncRNAs. Several different steps were used to validate differential expression including plotting the reads over

SUBMITTER: Ray MK 

PROVIDER: S-EPMC8844606 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature