Smoking behavior might affect allergic rhinitis and vasomotor rhinitis differently: A mendelian randomization appraisal.

ABSTRACT:

Background

Allergic rhinitis and vasomotor rhinitis are harassing numerous patients and their risk factors have not been well investigated. Here, we try to identify their risk factors and distinguish these 2 diseases.

Methods

A two-sample Mendelian randomization (MR) study was implemented to discover the risk factors of allergic and vasomotor rhinitis. Based on previous studies, we selected 15 potential risk factors and the genome-wide summary statistics were extracted from the non-FinnGen consortium. The genome-wide summary statistics of rhinitis were obtained from the FinnGen consortium. Both univariable MR and multivariable MR analyses were performed to identify the causal risk factors. The Cochrane's Q value was calculated to appraise the heterogeneity. MR-Egger intercep

SUBMITTER: Wang S 

PROVIDER: S-EPMC8844647 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature