Comparison and efficacy of two different sheep pox vaccines prepared from the Bakırkoy strain against lumpy skin disease in cattle.

ABSTRACT:

Purpose

Lumpy skin disease (LSD) is a highly contagious and economically important viral infection of cattle, which leads to financial losses in the livestock industry of affected countries. Vaccination is the most effective control measure to prevent the disease. Heterologous sheep pox (SP) vaccine was used against LSD in Turkey. In this research, it was aimed to adapt SP Bakırköy vaccine strain attenuated in lamb kidney cells to Madin-Darby bovine kidney (MDBK) cells to provide better protection than commercial SP vaccine in cattle.

Materials and methods

To evaluate safety and efficacy of vaccines, while animals were immunized with 10 doses (10^4.75 50% tissue culture infectious dose [TCID₅₀]) and 5 doses of SP vaccine (10⁴ TCID₅₀

SUBMITTER: Uzar S 

PROVIDER: S-EPMC8844671 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature