Cardiovascular Event Reporting in Modern Cancer Radiation Therapy Trials.

ABSTRACT:

Purpose

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in cancer survivors, particularly after chest radiation therapy (RT). However, the extent to which CVD events are consistently reported in contemporary prospective trials is unknown.

Methods and materials

From 10 high-impact RT, oncology, and medicine journals, we identified all latter phase trials from 2000 to 2019 enrolling patients with breast, lung, lymphoma, mesothelioma, or esophageal cancer wherein chest-RT was delivered. The primary outcome was the report of major adverse cardiac events (MACEs), defined as incident myocardial infarction, heart failure, coronary revascularization, arrhythmia, stroke, or CVD death across treatment arms. The secondary outcome was the report of any CVD e

SUBMITTER: Prasad RN 

PROVIDER: S-EPMC8844682 | biostudies-literature | 2022 Mar-Apr

REPOSITORIES: biostudies-literature