Drugging the Epigenome: Overcoming Resistance to Targeted and Immunotherapies in Melanoma.

ABSTRACT: This past decade has seen tremendous advances in understanding the molecular pathogenesis of melanoma and the development of novel effective therapies for melanoma. Targeted therapies and immunotherapies that extend survival of patients with advanced disease have been developed; however, the vast majority of patients experience relapse and therapeutic resistance over time. Moreover, cellular plasticity has been demonstrated to be a driver of therapeutic resistance mechanisms in melanoma and other cancers, largely functioning through epigenetic mechanisms, suggesting that targeting of the cancer epigenetic landscape may prove a worthwhile endeavor to ensure durable treatment responses and cures. Here, we review the epigenetic alterations that characterize melanoma development, progression,

SUBMITTER: Hanly A 

PROVIDER: S-EPMC8844701 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature