Engineering hyaluronic acid-based cryogels for CD44-mediated breast tumor reconstruction.

ABSTRACT: Breast cancer is a major health concern worldwide and is the leading cause of cancer-related death among American women. Traditional therapies, such as surgery, chemotherapy, and radiotherapy, are usually ineffective. Furthermore, cancer recurrence following targeted therapy often results from acquired drug resistance. Therefore, more realistic tumor models than monolayer cell culture for drug screening and discovery in an in vitro setting would facilitate the development of new therapeutic strategies. Toward this goal, we first developed a simple, rapid, low-cost, and high-throughput method for generating uniform multi-cellular tumor spheroids (MCTS) with controllable size. Next, biomimetic cryogel scaffolds fabricated from hyaluronic acid (HA) were utilized as a platform to recons

SUBMITTER: Rezaeeyazdi M 

PROVIDER: S-EPMC8844817 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature