Blood inflammatory phenotypes were associated with distinct clinical expressions of asthma in adults from a large population-based cohort.

ABSTRACT:

Background

Asthma is an inflammatory heterogeneous disease. Asthma inflammatory phenotypes based on blood eosinophil and neutrophil counts have never been identified and characterized in population-based studies.

Methods

Adults with current asthma and available blood eosinophil and neutrophil counts from the French population-based CONSTANCES cohort were included. Current asthma was defined by reports of asthma attacks, symptoms or treatments in the last 12 months. Inflammatory phenotypes were based on low (L) and high (H) blood (B) eosinophil (E) (LBE/HBE: 9/L, respectively) and neutrophil (N) (LBN/HBN: 9/L, respectively) cut-offs. Associations between inflammatory phenotypes and the clinical expressions of asthma were studied usin

SUBMITTER: Tsiavia T 

PROVIDER: S-EPMC8844864 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature