Behavior Effects of Structurally Diverse Per- and Polyfluoroalkyl Substances in Zebrafish.

ABSTRACT: Per- and polyfluoroalkyl substances (PFAS) are ubiquitously detected in the environment, and some pose significant human and environmental health concerns globally. While some PFAS induce adverse health effects, relatively few toxicological studies adequately address the broad structural diversity of this chemical class. In the current study, we evaluated 58 individual PFAS spanning 14 structural subclasses and 2 mixtures at single concentrations for developmental toxicity in zebrafish using highly sensitive behavior endpoints. Following developmental exposure to PFAS, zebrafish were assessed for mortality and challenged with an embryonic photomotor response (EPR) assay at 24 h postfertilization (hpf) and with larval photomotor response (LPR) and larval startle response assays at 120 hpf.

SUBMITTER: Rericha Y 

PROVIDER: S-EPMC8844880 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature