Carbon Catabolite Repression Governs Diverse Physiological Processes and Development in Aspergillus nidulans.

ABSTRACT: Carbon catabolite repression (CCR) is a common phenomenon of microorganisms that enable efficient utilization of carbon nutrients, critical for the fitness of microorganisms in the wild and for pathogenic species to cause infection. In most filamentous fungal species, the conserved transcription factor CreA/Cre1 mediates CCR. Previous studies demonstrated a primary function for CreA/Cre1 in carbon metabolism; however, the phenotype of creA/cre1 mutants indicated broader roles. The global function and regulatory mechanism of this wide-domain transcription factor has remained elusive. Here, we applied two powerful genomics methods (transcriptome sequencing and chromatin immunoprecipitation sequencing) to delineate the direct and indirect roles of Aspergillus nidulans CreA acros

SUBMITTER: Chen Y 

PROVIDER: S-EPMC8844935 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature